Dren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of specially engineered antibodies. Dren Bio's pipeline encompasses a multitude of programs from its two distinct, wholly-owned technologies. The Company's lead development candidate, DR-01, induces antibody-mediated killing of a specific cell type known to play a key role in various hematologic malignancies and autoimmune disorders. In addition to DR-01, the Company has launched multiple programs from its proprietary Targeted Myeloid Engager and Phagocytosis Platform, a bispecific antibody-based technology that offers a novel mechanism of action focused on selectively engaging myeloid cells (antigen presenting cells) for the targeted depletion of pathologic cells and other disease-causing agents.
Oncology Research
Senior Research Associate
Foster City, CA
Principal Scientist, Oncology Research
Dren Bio is seeking a highly talented and motivated Senior Research Associate to support our oncology efforts for the treatment of solid tumors. The ideal candidate should have work experience in an industrial setting and have a basic background of immunology and/or cell biology with strong technical experience. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research-stage programs into early clinical development. The candidate will perform in vitro and ex vivo studies to not only assess efficacy of our novel therapeutic agents but to also elucidate their impact on myeloid cell functions within the tumor microenvironment. Importantly, the successful candidate will be provided necessary training, support, and opportunities to grow and to present their work at various project-related meetings.
Perform in vitro/ ex vivo experiments to determine efficacy and MOA of therapeutic antibodies
Work collaboratively with other researchers to advance various therapeutic antibodies in different cancer indications
Specific tasks include recombinant cell line engineering, cell surface receptor quantification by flow, primary and cancer cell culture, isolation of immune cells from human blood, animal or human tissue processing, multi-color flow cytometry for immuno-phenotyping, cytokine profiling by MSD or Luminex, ADCC or ADCP assays using Incucyte and flow cytometry, DNA/RNA extraction for gene expression studies, various cellular assays (IP, western blot, and IF)
Meticulous record-keeping of scientific data, methods, and study designs
BA/BS or MS in a biology-related discipline with approximately 4+ years of experience in biopharmaceutical industry, or a combination of 4+ years of industrial and academic experience
Extensive experience in culturing variety of cancer cell lines including lymphoid & myeloid derived cell lines and primary cells
Experience with flow cytometry-based methods for characterizing cell surface expression
Transcript/protein quantification assays including qRT-PCR; RNA-seq, ELISA
Well-versed in various data processing and analysis software (e.g. FlowJo, Prism, ImageJ)
Detail-oriented, highly organized, and able to multi-task with multiple assignments
Strong written and verbal communication skills
Ability to work in a fast-paced environment and the flexibility to align daily work with project needs
Ability to set goals and prioritize tasks and resources to achieve superior work quality and efficiency
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. The base pay range for this position at commencement of employment is expected to be between $88,000 and $104,000 per year. At Dren Bio, pay ranges are determined by role, level(s), and location. The range displayed in this job posting reflects the minimum and maximum new hire pay for candidates located across all United States job markets. Within the range, individual pay will be determined by work location and additional factors, including job-related skills, experience, and relevant education or training. During the hiring process, Dren Bio’s Human Resources department can share more about the specific pay range based on the market location of the candidate.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
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