Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.
In vivo pharmacology
Senior Scientist
Foster City, CA
Associate Director, Immunology - Myeloid Biology
Dren Bio is seeking a highly motivated individual to serve as a scientific and technical lead for in vivo pharmacology. In this role, the candidate will contribute to the design and execution of rodent studies evaluating the efficacy, pharmacodynamic activity and mechanism of action of proprietary bispecific antibodies leveraging the company’s Targeted Myeloid Engager platform. The candidate will play a key role in identifying or developing relevant disease models and overseeing pharmacology work conducted in house or at CROs, with the goal of advancing early-stage programs to IND. This is an outstanding opportunity to work in a highly collaborative environment and play an integral role the discovery and development of novel therapeutics for cancer and other indications. The position offers exceptional opportunities for scientific and professional growth in a fast-paced, rapidly growing company.
Collaborate with research teams and consult literature to identify relevant animal models for the pharmacological evaluation of myeloid cell-engaging bispecific antibodies
Establish disease models (including rodent tumor models) in house or at CROs, and utilize these to demonstrate preclinical proof of concept for discovery-stage programs, evaluate potency and tolerability of tool or candidate antibodies, optimize therapeutic candidates, and answer mechanistic questions
Manage in vivo pharmacology studies conducted at CROs
Establish pharmacology workflow and systems for data acquisition, analysis, reporting and storage
Maintain thorough and timely documentation of all experiments
Mentor and/or manage team members in the design and execution of experimental work
Ensure compliance with IACUC approved protocols, guidelines and policies
Summarize and interpret pharmacology data for internal and external audiences
Contribute to scientific manuscripts, patent applications and regulatory documents
PhD or equivalent in pharmacology, immunology, or a related life science and 0-5 years of relevant experience or BS or MS in pharmacology, immunology or related field with 10+ years of experience
Strong background in in vivo pharmacology is required, including hands on experience with mouse tumor models (syngeneic, xenograft, humanized mouse models) and mammalian cell culture
Proficiency in rodent injection techniques (IV, SC, IP), tumor implantation and measurement, blood collection and tissue collection are required
Expertise in in vivo optical imaging and ex vivo analysis of rodent tissues e.g. by multicolor flow cytometry, in vitro functional assays, and gene expression analysis is highly desirable
Experience with data capture and analysis software (e.g. StudyLog, Prism, Excel) is required
Strong knowledge base in immunology, myeloid cell biology and the tumor microenvironment is a plus, as are prior experience with the use of syngeneic or humanized tumor models to study cancer immunotherapy, and experience with antibody-based therapeutics.
Self-motivated, with excellent problem-solving skills and willingness to learn
Ability to think proactively, manage multiple responsibilities, adapt to changing priorities and meet deadlines
Excellent interpersonal and communication skills, fostering a collaborative workplace environment
Ability to independently analyze and interpret data, with commitment to quality and scientific rigor
Previous management experience is a plus.
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company's total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate's experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com.
PDF VersionImmunology
Research Associate II / Senior Research Associate
Foster City, CA
Scientist II, Immunology
Dren Bio is seeking a bright and highly motivated and experienced research associate or senior research associate to support our targeted myeloid engager bispecific platform for the treatment of solid and liquid cancers, and non-oncology indications. The ideal candidate has extensive experience in a wide variety of techniques in the fields of immunology and cell and molecular biology. Strongest consideration will be given to candidates with strong technical experience with myeloid cell, T, or NK cell biology and background in the fields of cancer immunology. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research stage programs into early clinical development. The candidate is expected to execute and report in vitro, ex vivo and in vivo studies and be flexible in a fast-paced environment.
Execute in vivo studies (i.e. animal handling, performing IV/IP/SC injections, cell line inoculations, tumor volume measurements, tissue harvest and processing) and various in vitro and ex vivo studies
Isolate primary cells, including immune cells, from blood and tissues
Maintain cell lines or differentiate primary monocytes to different lineages
Design flow cytometric analysis panels and perform subsequent analyses on human and murine immune and/or tumor cells
Perform ADCC, ADCP, and other cell-based assays
Conduct biochemical assays and bead-based immunoassays (Western blot, ELISA, MSD, Luminex etc)
Adhere strictly to SOPs for non-clinical and clinical sample processing and flow cytometry analysis
Process, analyze and present data in project meetings
Work collaboratively with other researchers to advance various therapeutic antibodies in different cancer types and autoimmune indications
Keep detailed records of protocols and workflow
BS or MS degree in cell biology, immunology or related field, and 2+ years of experience in academia or biopharmaceutical industry.
Strong preference for candidates with hands-on expertise running in vivo studies and executing various animal handling procedures, such as IV/IP/SC injections, cell line inoculations, tumor volume measurements, tissue harvest
Broader knowledge of immunology and good technical expertise in cellular and molecular immunology
Routine literature search and communication with technical support to optimize and establish new techniques
Knowledge of sterile tissue culture techniques
Experience with tissue processing, primary cell isolation and culture
2+ years of multi-color flow cytometry
Experience with plate-based ELISAs, electrochemiluminescence (ECL)- based (e.g., MSD platform) and/or bead-based (e.g., Luminex multiplex platform) immunoassays
Data processing and analysis software (Flowjo, GraphPad Prism, ImageJ)
Excellent oral/written communication skills
Highly motivated and willing to adapt and learn new techniques to support drug development efforts
Engage to work collaboratively within teams to deliver exceptional results
Must be well organized, diligent, and willing to adapt to a fast-paced research environment
Experience with in vivo animal studies, including animal handling, performing routine injections, necropsy, collection of blood and tissues a strong plus
Immunohistochemistry a strong plus
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF VersionDren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct drug discovery programs. The Company’s first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides for a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.
Biologics Discovery
Research Associate II / Senior Research Associate
Foster City, CA
Scientist II, Biologics Discovery
Dren Bio is seeking a bright, highly motivated, and experienced research associate to add to the Biologics Group. The Biologics group is responsible for various functions critical for drug development such as: antibody discovery, molecular biology, cell line engineering, protein expression, protein purification, biophysical analytics, and functional cell assays. Multiple opportunities to cross train and learn additional skills.
Molecular biology design for protein expression
Managing plasmids for expression
Transient expression of antibody and antigens in cell systems
Characterize purified antibodies in variety of ways (Protein or Cell binding)
Preform cell-based experiments to validate protein design concepts
Bachelors or Masters in biochemistry, molecular biology, or related field
Industry experience preferred.
Technical expertise in molecular biology with proficiency in generating constructs for production of antibody and bispecific molecules
Transient expression in HEK293 and CHO systems
Excellent sterile tissue culture technique for routine maintenance of primary and cancer cell lines and subsequent implementation in cell based assays
Good documentation, organization, and communication skills
Highly motivated with ability to work collaboratively in a team environment
Single color or multi-color flow cytometry
Functional protein characterization by ELISA or Octet
Primary cell isolation from blood
Data processing and analysis software (FlowJo, GraphPad Prism, Geneious)
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF VersionDren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.
Protein Sciences
Research Associate I
Foster City, CA
Scientist II, Protein Sciences
Dren Bio is seeking an outstanding, highly motivated individual to support protein production for our discovery programs. The successful candidate will be a member of the Protein Sciences team and support protein production utilizing mammalian protein expression, purification, and characterization. This position offers excellent potential for contribution and visibility at an early-stage company and opportunities for career development. This is a Temp to Hire position.
As an integral member of the Protein Sciences group, this individual will work closely with other team members and partner with other functional areas in the organization
Production of proteins for Research and pre-clinical activities
Protein expression in mammalian system in transient and stable format
Protein purification using affinity and other chromatography methods
Cryopreservation of cell lines and clarification of production medium
Protein quantification, SDS-PAGE, size exclusion HPLC, other analytical methods as appropriate
Materials management and inventory maintenance
Maintenance of electronic lab notebook and databases, preparation of reports, and regular presentations to summarize results and update management
BS degree in biological sciences (biochemistry, cell biology, molecular biology) with 1-3 years experience in the biopharmaceutical industry
Familiarity with mammalian protein expression systems in transient and stable formats, protein purification of monoclonal antibody and other proteins using affinity and other chromatography techniques
Proficiency in aseptic technique, cell line maintenance, and host cell transfection
Experience with analytical methods such as SDS-PAGE, size exclusion HPLC, ELISA, Octet and other methods for protein characterization
Capacity for learning new techniques and handling diverse tasks concurrently
Ability to collaborate and communicate well with colleagues
Ability to work independently or with limited direct supervision
The ideal candidate will be meticulous, highly organized, pay great attention to detail, deliver consistent results, and work under aggressive timelines
The ideal candidate will have strong technical aptitude for lab and instrument work, and a problem-solving mindset that is diligent and flexible
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF VersionDren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.
Data Management
Senior Clinical Data Manager
Foster City, CA (partially remote)
VP, Clinical Operations
The Senior Clinical Data Manager provides oversight for the execution of data management activities at the program level (for an indication or for multiple studies within an indication) from start up through to regulatory submission. Serves as the lead study data manager on the study team(s) and in collaboration with external vendors. Designs, implements, and maintains electronic case report forms, clinical trial database and electronic data checks for ongoing and new clinical research studies. Develops, implements, and executes data review plans to ensure quality of collected clinical data, including oversight of multi-functional data review teams. Manages electronic data received from clinical sites, data transfers and reconciliations, and the development of technical study documents and reports such as data transfer plans, annotated case report forms and database/data quality metrics.
Responsible for overseeing and supporting data management activities for assigned projects in accordance with ICH/GCP, GCDMP and other relevant procedures and guidelines.
Provide a high level of expertise in data management to support clinical studies.
Ensure the quality of clinical data meets standards for regulatory submission, publications, and other high-profile business activities.
As the main point of contact to the Study Team, work collaboratively with Clinical Operations, vendors, statistical programmers, Clinical Development, Safety/PVG, Regulatory and Project Management functions to meet data management deliverables and clinical trial timelines.
Manages data extractions and/or provides simple data listings for safety review meetings and other meetings as needed.
Monitor data management processes and CRO performance to ensure study deliverables and timelines are met.
Responsible for eCRF design, development, validation, and maintenance of clinical study database(s) for clinical trials in collaboration with vendor(s).
Generate and implement the Data Review Plan (DRP) defining and documenting the data quality review strategy and procedures for data quality review and data acceptance prior to data analyses and/or database lock for each clinical trial in collaboration with cross-functional team.
Oversee/perform data review and cleaning activities, assuring quality interim and final reporting of clinical data.
Lead the set-up and validation of vendor data transfer, data cleaning activities, generation and approval of data management documents, generation and distribution of data management metrics, data listings and status reports.
Manage data transfers with CROs and third-party data sources, SAE/AE reconciliation and MedDRA/WHO-DD coding.
Provide clear verbal or written information and hands-on support to project team members and to CROs related to eCRF and database design, data quality, and reporting of database/data quality status.
Identify and mitigate risks to data management deliverables.
Collaborate cross-functionally to resolve or escalate data management issues and ensure effective communication throughout all clinical trial phases.
Oversee the transfer, locking, and archiving of study databases.
Manage scheduling and time constrains across multiple projects.
Prepare recommendations for new or improved processes for data management and data flow.
Contribute to the ongoing development, review, and revisions of data management SOPs and standard DM templates, as needed.
BS/BA degree and a minimum of 9 years of related experience; or MS/MA degree and 7 years of related experienced or equivalent.
A minimum of 5 years of clinical data management experience in the pharmaceutical industry or clinical trials.
Oncology experience required; experience with lymphomas a bonus.
A minimum of 4 years in a project leadership role.
Experience working in an outsourced data management model.
Experience with Electronic Data Capture (EDC) is required, preferably with Viedoc.
Experience with IRT systems preferred.
Highly collaborative and demonstrated ability to work well in teams in a cross functional manner.
Knowledge of ICH/GCP, GCDMP and other relevant procedures and guidelines.
General knowledge of FDA regulations that govern the execution of clinical trials and EDC systems.
Identifies and implements methods and procedures to achieve results.
Leads or manages the work of others by providing guidance to subordinates or teams based on company goals, with responsibility for results.
Performs and is able to prioritize a variety of complicated tasks with a large degree of creativity and latitude.
Has complete understanding and wide application of technical principles, theories, concepts, and techniques.
Has a good knowledge of other related disciplines.
Ability to communicate and work independently with scientific/technical personnel.
Ability to think critically and demonstrated troubleshooting and problem-solving skills.
Self-motivated and willing to accept temporary responsibilities outside of initial job description.
Comfortable in a fast-paced company environment with minimal direction and able to adjust workload based upon changing priorities.
Excellent verbal and written communication skills, including presentation and interpersonal skills.
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF VersionDren Bio (the "Company") is a privately held, clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company's management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio's pipeline is currently comprised of two distinct drug discovery programs. The Company's first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company's second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.
Program Management
Senior Manager/Director, depending on experience
Redwood City, CA
Head of Strategy and Portfolio Management
Dren Bio is seeking a highly motivated Program Management Lead to drive execution of project, operational, and strategic initiatives for the Company’s clinical-stage Enhanced ADCC program. As part of the Program & Alliance Management team, the successful candidate will partner with functional leaders and multi-disciplinary teams to develop and maintain detailed project plans and ensure timely completion of R&D activities and deliverables associated with the Company’s corporate strategy and objectives. Effective communication, attention to detail, and collaborative leadership skills are essential. This position offers the potential to play a key role in the advancement of Dren’s Enhanced ADCC program as well as opportunities for career growth in a fast-paced, dynamic environment.
Partner with functional leaders and multi-disciplinary teams to define project objectives, develop plans, budgets and timelines for the Company’s clinical-stage Enhanced ADCC program; oversee execution of project plans through key development, clinical and regulatory stages across multiple indications
Monitor and track the project(s) against approved timelines, budgets and milestones; maintain cross functional alignment and accountability to agreed team objectives and deliverables
Coordinate and lead project team meetings and/or development strategy meetings, including the creation of meeting agendas, documentation of decisions, action items and issues; liaise across functions to ensure transparency across project team
Anticipate project gaps, barriers and risks, identify solutions to proactively respond and develop risk mitigation plans; escalate issues, as appropriate, and join together relevant team members to problem-solve
Maintain frequent communication with project team members, key stakeholders, and supervisor to convey project status, risks, progress toward milestones/deliverables, and changes in scope, budget, or timeline.
Maintain project documentation and accurate records; create and manage project dashboards, trackers, and other project management or productivity tools
Build and foster strong working relationships with project team members and key stakeholders to promote effective collaboration and optimal team performance
Prepare and monitor financial forecasts
Provide administrative support, as needed, including calendaring, RFPs, contract review, logistics
Report to and work closely with the Head of Strategy and Portfolio Management to ensure project status, budget and timeline are aligned with corporate objectives, budget, and timeline
BA/BS or higher degree in life sciences, chemistry, engineering, or equivalent related discipline with 8+ years of relevant experience in the biopharmaceutical industry.
The ideal candidate will have a scientific background and 2-5 years of project management experience in late- stage biologics drug development.
PMP certification is a plus.
Team player with high emotional intelligence who is organized, diligent, and thoughtful with outstanding leadership, communication, and project management skills.
Skillful use of interpersonal skills and influence to drive results and meet project objectives without formal authority over internal and external team members.
Self-directed and proactive with ability to function independently in certain situations, exercise good judgment and respond quickly and effectively to changing environments.
Adaptable in the face of uncertainty, responds to unanticipated challenges in a constructive manner and able to generate options for moving forward.
Ability to distill, organize, and effectively communicate (verbal and written) key messages from complex discussions and translate strategy into action.
Adept at time management and navigating competing and changing priorities in a fast-paced, rapid-growth environment.
Technical and/or project management experience in development of a biologic product is required.
Demonstrated experience building and managing relationships, teams, budgets, and timelines.
Experience with conflict resolution, critical thinking, and problem solving in real time.
Working knowledge of project management tools; strong computer skills and proficiency in Microsoft Office, SharePoint, Smartsheet, Box.
Adequate knowledge of GxP, technical operations and CMC; familiarity with US and EU regulatory interactions including pre-IND, IND, EOP meetings, and BLA.
Understanding of biologics drug development spanning preclinical, clinical (Ph1,2,3), technical operations/CMC, and regulatory functions.
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company's total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate's experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF Version