Immunology
Research Associate II / Senior Research Associate
Foster City, CA
Scientist II, Immunology
Dren Bio is seeking a bright and highly motivated and experienced research associate or senior research associate to support our targeted myeloid engager bispecific platform for the treatment of solid and liquid cancers, and non-oncology indications. The ideal candidate has extensive experience in a wide variety of techniques in the fields of immunology and cell and molecular biology. Strongest consideration will be given to candidates with strong technical experience with myeloid cell, T, or NK cell biology and background in the fields of cancer immunology. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research stage programs into early clinical development. The candidate is expected to execute and report in vitro, ex vivo and in vivo studies and be flexible in a fast-paced environment.
Execute in vivo studies (i.e. animal handling, performing IV/IP/SC injections, cell line inoculations, tumor volume measurements, tissue harvest and processing) and various in vitro and ex vivo studies
Isolate primary cells, including immune cells, from blood and tissues
Maintain cell lines or differentiate primary monocytes to different lineages
Design flow cytometric analysis panels and perform subsequent analyses on human and murine immune and/or tumor cells
Perform ADCC, ADCP, and other cell-based assays
Conduct biochemical assays and bead-based immunoassays (Western blot, ELISA, MSD, Luminex etc)
Adhere strictly to SOPs for non-clinical and clinical sample processing and flow cytometry analysis
Process, analyze and present data in project meetings
Work collaboratively with other researchers to advance various therapeutic antibodies in different cancer types and autoimmune indications
Keep detailed records of protocols and workflow
BS or MS degree in cell biology, immunology or related field, and 2+ years of experience in academia or biopharmaceutical industry.
Strong preference for candidates with hands-on expertise running in vivo studies and executing various animal handling procedures, such as IV/IP/SC injections, cell line inoculations, tumor volume measurements, tissue harvest
Broader knowledge of immunology and good technical expertise in cellular and molecular immunology
Routine literature search and communication with technical support to optimize and establish new techniques
Knowledge of sterile tissue culture techniques
Experience with tissue processing, primary cell isolation and culture
2+ years of multi-color flow cytometry
Experience with plate-based ELISAs, electrochemiluminescence (ECL)- based (e.g., MSD platform) and/or bead-based (e.g., Luminex multiplex platform) immunoassays
Data processing and analysis software (Flowjo, GraphPad Prism, ImageJ)
Excellent oral/written communication skills
Highly motivated and willing to adapt and learn new techniques to support drug development efforts
Engage to work collaboratively within teams to deliver exceptional results
Must be well organized, diligent, and willing to adapt to a fast-paced research environment
Experience with in vivo animal studies, including animal handling, performing routine injections, necropsy, collection of blood and tissues a strong plus
Immunohistochemistry a strong plus
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF VersionDren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.
Immunology
Scientist
Foster City, CA
Senior Scientist I, Immunology
Dren Bio is seeking a highly talented and motivated scientist to support our Targeted Myeloid Engager platform for the treatment of solid and hematological cancers. The ideal candidate is an expert in macrophage and/or dendritic cell biology with strong technical experience in probing how myeloid cells contribute to disease pathogenesis or could be restored to treat cancer and inflammatory disease. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research stage programs into early clinical development. The candidate will be expected to perform essential ex vivo and in vivo studies to not only assess efficacy of our novel therapeutic agents but to elucidate their impact on macrophage and dendritic cell functions in the tumor microenvironment. Importantly, the successful candidate will be provided necessary training, support, and opportunities to grow into and lead a therapeutic program or project sub-teams, and mentor other researchers.
Work collaboratively with other researchers to advance various therapeutic antibodies in different cancer types
Design, conduct, and interpret high quality ex vivo studies (e.g. ADCC, ADCP, cytokine profiling, gene expression profiling) and in vivo studies (e.g. syngeneic, xenograft, and/or humanized mouse models of cancer) to evaluate efficacy and mechanism of action (MOA) of Dren Bio’s novel therapeutic agents
Specific tasks include animal or human tissue processing, multi-color flow cytometry for immuno-phenotyping, cytokine profiling by MSD or Luminex, ADCC or ADCP assays using Incucyte live-cell imaging and flow cytometry, IHC/IF and confocal microscopy, DNA/RNA extraction for gene expression studies, various biochemical techniques (IP, western blot, IHC, and IF)
Develop and execute assays to evaluate antigen presentation by macrophages and dendritic cells, and T cell activation
Well-versed in various data processing and analysis software (e.g. FlowJo, Prism, ImageJ)
Mentor and train other scientists on novel tools and techniques
Become a project leader for a specific therapeutic program, while demonstrating flexibility and enthusiasm to support evolving company goals that are inherent of a fast-paced start-up environment
Meticulous record-keeping of scientific data, methods, and study designs
Present data in various forums, including lab meetings, department meetings, and multi-functional project teams
Publish scientific and methodological results in high quality journals
PhD in Immunology, Cancer Biology, Biochemistry, or related discipline with approximately 0-3+ years of experience in academia or biopharmaceutical industry.
The candidate is expected to have in-depth training in immunology and rich technical expertise in cellular and molecular immunology
Routine literature search and keeping up to date of the competitive landscape of immuno-oncology
Strong expertise in animal or human tissue processing and downstream assays (i.e. immuno-phenotyping by multi-color flow cytometry, immunohistochemistry, cell-based functional assays, biochemical assays)
Hands-on experience in designing and executing in vivo studies (e.g. syngeneic, xenograft, PDX, humanized mouse models of immuno-oncology)
Proficiency in IP, IV, SC and PO dosing, blood and tissue collection are required
Experience with primary cell isolation and culture
Must have a record of successful scientific accomplishments as evidenced by one or more first-author papers published or accepted in a well-recognized and peer-reviewed journals
Strong analytical and critical thinking skills with the ability to interpret complex data and highly motivated to learn and support the drug development efforts
Motivated self-starter who can work independently and collaboratively in a dynamic team environment with a proactive attitude
Excellent written and verbal communication skills
Ability to work in a fast-paced environment and the flexibility to align daily work with project needs
Ability to set goals and prioritize tasks and resources to achieve superior work quality and efficiency
Must be well organized, have a strong work ethic, attention to detail and be diligent in data documentation
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com.
PDF VersionDren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.
Protein Sciences
Research Associate I
Foster City, CA
Scientist II, Protein Sciences
Dren Bio is seeking an outstanding, highly motivated individual to support protein production for our discovery programs. The successful candidate will be a member of the Protein Sciences team and support protein production utilizing mammalian protein expression, purification, and characterization. This position offers excellent potential for contribution and visibility at an early-stage company and opportunities for career development. This is a Temp to Hire position.
As an integral member of the Protein Sciences group, this individual will work closely with other team members and partner with other functional areas in the organization
Production of proteins for Research and pre-clinical activities
Protein expression in mammalian system in transient and stable format
Protein purification using affinity and other chromatography methods
Cryopreservation of cell lines and clarification of production medium
Protein quantification, SDS-PAGE, size exclusion HPLC, other analytical methods as appropriate
Materials management and inventory maintenance
Maintenance of electronic lab notebook and databases, preparation of reports, and regular presentations to summarize results and update management
BS degree in biological sciences (biochemistry, cell biology, molecular biology) with 1-3 years experience in the biopharmaceutical industry
Familiarity with mammalian protein expression systems in transient and stable formats, protein purification of monoclonal antibody and other proteins using affinity and other chromatography techniques
Proficiency in aseptic technique, cell line maintenance, and host cell transfection
Experience with analytical methods such as SDS-PAGE, size exclusion HPLC, ELISA, Octet and other methods for protein characterization
Capacity for learning new techniques and handling diverse tasks concurrently
Ability to collaborate and communicate well with colleagues
Ability to work independently or with limited direct supervision
The ideal candidate will be meticulous, highly organized, pay great attention to detail, deliver consistent results, and work under aggressive timelines
The ideal candidate will have strong technical aptitude for lab and instrument work, and a problem-solving mindset that is diligent and flexible
Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.
Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.
Please send resume and cover letter to careers@drenbio.com
PDF Version