Careers

Research & Nonclinical Development

Function:

Immunology

Level:

Research Associate II / Senior Research Associate

Location:

Foster City, CA

Reporting Manager:

Scientist II, Immunology

About the Opportunity:

Dren Bio is seeking a bright and highly motivated and experienced research associate or senior research associate to support our targeted myeloid engager bispecific platform for the treatment of solid and liquid cancers, and non-oncology indications. The ideal candidate has extensive experience in a wide variety of techniques in the fields of immunology and cell and molecular biology. Strongest consideration will be given to candidates with strong technical experience with myeloid cell, T, or NK cell biology and background in the fields of cancer immunology. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research stage programs into early clinical development. The candidate is expected to execute and report in vitro, ex vivo and in vivo studies and be flexible in a fast-paced environment.

Role and Responsibilities:
  • Execute in vivo studies (i.e. animal handling, performing IV/IP/SC injections, cell line inoculations, tumor volume measurements, tissue harvest and processing) and various in vitro and ex vivo studies

  • Isolate primary cells, including immune cells, from blood and tissues

  • Maintain cell lines or differentiate primary monocytes to different lineages

  • Design flow cytometric analysis panels and perform subsequent analyses on human and murine immune and/or tumor cells

  • Perform ADCC, ADCP, and other cell-based assays

  • Conduct biochemical assays and bead-based immunoassays (Western blot, ELISA, MSD, Luminex etc)

  • Adhere strictly to SOPs for non-clinical and clinical sample processing and flow cytometry analysis

  • Process, analyze and present data in project meetings

  • Work collaboratively with other researchers to advance various therapeutic antibodies in different cancer types and autoimmune indications

  • Keep detailed records of protocols and workflow

Education, Experience and Qualification Requirements:
  • BS or MS degree in cell biology, immunology or related field, and 2+ years of experience in academia or biopharmaceutical industry.

Core Competencies, Knowledge and Skill Requirements:
  • Strong preference for candidates with hands-on expertise running in vivo studies and executing various animal handling procedures, such as IV/IP/SC injections, cell line inoculations, tumor volume measurements, tissue harvest

  • Broader knowledge of immunology and good technical expertise in cellular and molecular immunology

  • Routine literature search and communication with technical support to optimize and establish new techniques

  • Knowledge of sterile tissue culture techniques

  • Experience with tissue processing, primary cell isolation and culture

  • 2+ years of multi-color flow cytometry

  • Experience with plate-based ELISAs, electrochemiluminescence (ECL)- based (e.g., MSD platform) and/or bead-based (e.g., Luminex multiplex platform) immunoassays

  • Data processing and analysis software (Flowjo, GraphPad Prism, ImageJ)

  • Excellent oral/written communication skills

  • Highly motivated and willing to adapt and learn new techniques to support drug development efforts

  • Engage to work collaboratively within teams to deliver exceptional results

  • Must be well organized, diligent, and willing to adapt to a fast-paced research environment

  • Experience with in vivo animal studies, including animal handling, performing routine injections, necropsy, collection of blood and tissues a strong plus

  • Immunohistochemistry a strong plus

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version
About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct drug discovery programs. The Company’s first program surrounds DR-01, its lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program surrounds its Targeted Myeloid Engager and Phagocytosis Platform, a proprietary bispecific antibody-based technology that provides for a novel mechanism of action to selectively engage myeloid cells for (1) targeted depletion of pathologic cells and other disease-inducing agents and (2) inducing localized immunostimulation. The engagement of antigen presenting cells has the potential to elicit a sustained, durable response.

Function:

Biologics Discovery

Level:

Research Associate II / Senior Research Associate

Location:

Foster City, CA

Reporting Manager:

Scientist II, Biologics Discovery

About the Opportunity:

Dren Bio is seeking a bright, highly motivated, and experienced research associate to add to the Biologics Group. The Biologics group is responsible for various functions critical for drug development such as: antibody discovery, molecular biology, cell line engineering, protein expression, protein purification, biophysical analytics, and functional cell assays. Multiple opportunities to cross train and learn additional skills.

Role and Responsibilities:
  • Molecular biology design for protein expression

  • Managing plasmids for expression

  • Transient expression of antibody and antigens in cell systems

  • Characterize purified antibodies in variety of ways (Protein or Cell binding)

  • Preform cell-based experiments to validate protein design concepts

Education, Experience and Qualification Requirements:
  • Bachelors or Masters in biochemistry, molecular biology, or related field

  • Industry experience preferred.

Core Competencies, Knowledge and Skill Requirements:
  • Technical expertise in molecular biology with proficiency in generating constructs for production of antibody and bispecific molecules

  • Transient expression in HEK293 and CHO systems

  • Excellent sterile tissue culture technique for routine maintenance of primary and cancer cell lines and subsequent implementation in cell based assays

  • Good documentation, organization, and communication skills

  • Highly motivated with ability to work collaboratively in a team environment

  • Single color or multi-color flow cytometry

  • Functional protein characterization by ELISA or Octet

  • Primary cell isolation from blood

  • Data processing and analysis software (FlowJo, GraphPad Prism, Geneious)

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version
About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.

Function:

Immunology

Level:

Scientist

Location:

Foster City, CA

Reporting Manager:

Senior Scientist I, Immunology

About the Opportunity:

Dren Bio is seeking a highly talented and motivated scientist to support our Targeted Myeloid Engager platform for the treatment of solid and hematological cancers. The ideal candidate is an expert in macrophage and/or dendritic cell biology with strong technical experience in probing how myeloid cells contribute to disease pathogenesis or could be restored to treat cancer and inflammatory disease. The candidate will work with a cross-functional team of scientists (immunologists, cell biologists, biochemists, and protein engineers) to advance research stage programs into early clinical development. The candidate will be expected to perform essential ex vivo and in vivo studies to not only assess efficacy of our novel therapeutic agents but to elucidate their impact on macrophage and dendritic cell functions in the tumor microenvironment. Importantly, the successful candidate will be provided necessary training, support, and opportunities to grow into and lead a therapeutic program or project sub-teams, and mentor other researchers.

Role and Responsibilities:
  • Work collaboratively with other researchers to advance various therapeutic antibodies in different cancer types

  • Design, conduct, and interpret high quality ex vivo studies (e.g. ADCC, ADCP, cytokine profiling, gene expression profiling) and in vivo studies (e.g. syngeneic, xenograft, and/or humanized mouse models of cancer) to evaluate efficacy and mechanism of action (MOA) of Dren Bio’s novel therapeutic agents

  • Specific tasks include animal or human tissue processing, multi-color flow cytometry for immuno-phenotyping, cytokine profiling by MSD or Luminex, ADCC or ADCP assays using Incucyte live-cell imaging and flow cytometry, IHC/IF and confocal microscopy, DNA/RNA extraction for gene expression studies, various biochemical techniques (IP, western blot, IHC, and IF)

  • Develop and execute assays to evaluate antigen presentation by macrophages and dendritic cells, and T cell activation

  • Well-versed in various data processing and analysis software (e.g. FlowJo, Prism, ImageJ)

  • Mentor and train other scientists on novel tools and techniques

  • Become a project leader for a specific therapeutic program, while demonstrating flexibility and enthusiasm to support evolving company goals that are inherent of a fast-paced start-up environment

  • Meticulous record-keeping of scientific data, methods, and study designs

  • Present data in various forums, including lab meetings, department meetings, and multi-functional project teams

  • Publish scientific and methodological results in high quality journals

Education, Experience and Qualification Requirements:
  • PhD in Immunology, Cancer Biology, Biochemistry, or related discipline with approximately 0-3+ years of experience in academia or biopharmaceutical industry.

Core Competencies, Knowledge and Skill Requirements:
  • The candidate is expected to have in-depth training in immunology and rich technical expertise in cellular and molecular immunology

  • Routine literature search and keeping up to date of the competitive landscape of immuno-oncology

  • Strong expertise in animal or human tissue processing and downstream assays (i.e. immuno-phenotyping by multi-color flow cytometry, immunohistochemistry, cell-based functional assays, biochemical assays)

  • Hands-on experience in designing and executing in vivo studies (e.g. syngeneic, xenograft, PDX, humanized mouse models of immuno-oncology)

  • Proficiency in IP, IV, SC and PO dosing, blood and tissue collection are required

  • Experience with primary cell isolation and culture

  • Must have a record of successful scientific accomplishments as evidenced by one or more first-author papers published or accepted in a well-recognized and peer-reviewed journals

  • Strong analytical and critical thinking skills with the ability to interpret complex data and highly motivated to learn and support the drug development efforts

  • Motivated self-starter who can work independently and collaboratively in a dynamic team environment with a proactive attitude

  • Excellent written and verbal communication skills

  • Ability to work in a fast-paced environment and the flexibility to align daily work with project needs

  • Ability to set goals and prioritize tasks and resources to achieve superior work quality and efficiency

  • Must be well organized, have a strong work ethic, attention to detail and be diligent in data documentation

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com.

PDF Version

Process Sciences & Manufacturing Operations

About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.

Function:

Protein Sciences

Level:

Research Associate I

Location:

Foster City, CA

Reporting Manager:

Scientist II, Protein Sciences

About the Opportunity:

Dren Bio is seeking an outstanding, highly motivated individual to support protein production for our discovery programs. The successful candidate will be a member of the Protein Sciences team and support protein production utilizing mammalian protein expression, purification, and characterization. This position offers excellent potential for contribution and visibility at an early-stage company and opportunities for career development. This is a Temp to Hire position.

Role and Responsibilities:
  • As an integral member of the Protein Sciences group, this individual will work closely with other team members and partner with other functional areas in the organization

  • Production of proteins for Research and pre-clinical activities

  • Protein expression in mammalian system in transient and stable format

  • Protein purification using affinity and other chromatography methods

  • Cryopreservation of cell lines and clarification of production medium

  • Protein quantification, SDS-PAGE, size exclusion HPLC, other analytical methods as appropriate

  • Materials management and inventory maintenance

  • Maintenance of electronic lab notebook and databases, preparation of reports, and regular presentations to summarize results and update management

Education, Experience and Qualification Requirements:
  • BS degree in biological sciences (biochemistry, cell biology, molecular biology) with 1-3 years experience in the biopharmaceutical industry

Core Competencies, Knowledge and Skill Requirements:
  • Familiarity with mammalian protein expression systems in transient and stable formats, protein purification of monoclonal antibody and other proteins using affinity and other chromatography techniques

  • Proficiency in aseptic technique, cell line maintenance, and host cell transfection

  • Experience with analytical methods such as SDS-PAGE, size exclusion HPLC, ELISA, Octet and other methods for protein characterization

  • Capacity for learning new techniques and handling diverse tasks concurrently

  • Ability to collaborate and communicate well with colleagues

  • Ability to work independently or with limited direct supervision

  • The ideal candidate will be meticulous, highly organized, pay great attention to detail, deliver consistent results, and work under aggressive timelines

  • The ideal candidate will have strong technical aptitude for lab and instrument work, and a problem-solving mindset that is diligent and flexible

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version

Clinical

About the Company:

Dren Bio (the “Company”) is a privately held, pre-clinical stage biopharmaceutical company focused on developing therapeutic antibodies for the treatment of cancer, autoimmune and other serious diseases. The Company’s management team and scientific advisors have profound expertise covering the discovery and development of engineered antibodies designed to selectively target and deplete pathological cells. Dren Bio’s pipeline is currently comprised of two distinct programs. The first program surrounds DR-01, the Company’s lead product candidate, which induces antibody-mediated killing of a cell type that is responsible for a multitude of hematologic malignancies and plays a key role in various autoimmune diseases. The Company’s second program is a proprietary antibody-based technology platform, its Targeted Myeloid Engager, which utilizes a novel mechanism of action to selectively engage myeloid cells for the targeted depletion of diseased cells and disease-inducing agents, as well as to induce immunostimulation.

Function:

Data Management

Level:

Senior Clinical Data Manager

Location:

Foster City, CA (partially remote)

Reporting Manager:

VP, Clinical Operations

About the Opportunity:

The Senior Clinical Data Manager provides oversight for the execution of data management activities at the program level (for an indication or for multiple studies within an indication) from start up through to regulatory submission. Serves as the lead study data manager on the study team(s) and in collaboration with external vendors. Designs, implements, and maintains electronic case report forms, clinical trial database and electronic data checks for ongoing and new clinical research studies. Develops, implements, and executes data review plans to ensure quality of collected clinical data, including oversight of multi-functional data review teams. Manages electronic data received from clinical sites, data transfers and reconciliations, and the development of technical study documents and reports such as data transfer plans, annotated case report forms and database/data quality metrics.

Role and Responsibilities:
  • Responsible for overseeing and supporting data management activities for assigned projects in accordance with ICH/GCP, GCDMP and other relevant procedures and guidelines.

  • Provide a high level of expertise in data management to support clinical studies.

  • Ensure the quality of clinical data meets standards for regulatory submission, publications, and other high-profile business activities.

  • As the main point of contact to the Study Team, work collaboratively with Clinical Operations, vendors, statistical programmers, Clinical Development, Safety/PVG, Regulatory and Project Management functions to meet data management deliverables and clinical trial timelines.

  • Manages data extractions and/or provides simple data listings for safety review meetings and other meetings as needed.

  • Monitor data management processes and CRO performance to ensure study deliverables and timelines are met.

  • Responsible for eCRF design, development, validation, and maintenance of clinical study database(s) for clinical trials in collaboration with vendor(s).

  • Generate and implement the Data Review Plan (DRP) defining and documenting the data quality review strategy and procedures for data quality review and data acceptance prior to data analyses and/or database lock for each clinical trial in collaboration with cross-functional team.

  • Oversee/perform data review and cleaning activities, assuring quality interim and final reporting of clinical data.

  • Lead the set-up and validation of vendor data transfer, data cleaning activities, generation and approval of data management documents, generation and distribution of data management metrics, data listings and status reports.

  • Manage data transfers with CROs and third-party data sources, SAE/AE reconciliation and MedDRA/WHO-DD coding.

  • Provide clear verbal or written information and hands-on support to project team members and to CROs related to eCRF and database design, data quality, and reporting of database/data quality status.

  • Identify and mitigate risks to data management deliverables.

  • Collaborate cross-functionally to resolve or escalate data management issues and ensure effective communication throughout all clinical trial phases.

  • Oversee the transfer, locking, and archiving of study databases.

  • Manage scheduling and time constrains across multiple projects.

  • Prepare recommendations for new or improved processes for data management and data flow.

  • Contribute to the ongoing development, review, and revisions of data management SOPs and standard DM templates, as needed.

Education, Experience and Qualification Requirements:
  • BS/BA degree and a minimum of 9 years of related experience; or MS/MA degree and 7 years of related experienced or equivalent.

  • A minimum of 5 years of clinical data management experience in the pharmaceutical industry or clinical trials.

  • Oncology experience required; experience with lymphomas a bonus.

  • A minimum of 4 years in a project leadership role.

Core Competencies, Knowledge and Skill Requirements:
  • Experience working in an outsourced data management model.

  • Experience with Electronic Data Capture (EDC) is required, preferably with Viedoc.

  • Experience with IRT systems preferred.

  • Highly collaborative and demonstrated ability to work well in teams in a cross functional manner.

  • Knowledge of ICH/GCP, GCDMP and other relevant procedures and guidelines.

  • General knowledge of FDA regulations that govern the execution of clinical trials and EDC systems.

  • Identifies and implements methods and procedures to achieve results.

  • Leads or manages the work of others by providing guidance to subordinates or teams based on company goals, with responsibility for results.

  • Performs and is able to prioritize a variety of complicated tasks with a large degree of creativity and latitude.

  • Has complete understanding and wide application of technical principles, theories, concepts, and techniques.

  • Has a good knowledge of other related disciplines.

  • Ability to communicate and work independently with scientific/technical personnel.

  • Ability to think critically and demonstrated troubleshooting and problem-solving skills.

  • Self-motivated and willing to accept temporary responsibilities outside of initial job description.

  • Comfortable in a fast-paced company environment with minimal direction and able to adjust workload based upon changing priorities.

  • Excellent verbal and written communication skills, including presentation and interpersonal skills.

Salaries, Benefits and Other Employee Perks:

Dren Bio strongly believes in investing in, and rewarding, its employees. This philosophy is embodied in the Company’s total rewards program, which includes competitive cash compensation, equity incentive awards, and employer sponsored benefit offerings. Exact cash and equity compensation shall be commensurate with candidate’s experience and qualifications.

Employment Practices:

Dren Bio is an equal opportunity employer. Employment decisions are based on merit and business needs. Dren Bio will not discriminate against any job applicant because of race, color, national origin, ancestry, gender, sexual orientation, age, religion, creed, physical or mental disability, gender identity, medical condition, pregnancy, marital status, veteran status, or any other characteristic protected by federal, state or local law.

Interested Applicants:

Please send resume and cover letter to careers@drenbio.com

PDF Version

General & Administrative